Our first activity is turned to the animal world and we propose to measure a new bological constant, that can be used as a marker of health status for animals tumor affection.
The objective is to do prognosis (treatment effectiveness versus relapse) as part of a therapeutic follow-up, or suggestive of a phenomenon of tumor transformation at the deteriorating health condition without apparent cause. For this, only a small amount of whole blood or serum (< 1 mL ) is required. The strength of this technique is that it relies on measurement of oxidative stress applied to the transformed cells of the individual in an anti-tumor lymphocyte response (cytotoxic CD8 + T lymphocytes) . This produces a variation in the isotopic composition of copper which is the quantity measured by our advanced analytical techniques . This method is a complete break with the usual biomarkers that are either protein or genetic and ultimately very similar .
We use the isotopic composition of copper as a biomarker because it has a very fast evolution and correlated to the efficiency or the escape of the treatment. The other advantage is that the isotopic copper variation is a very robust biomarker in terms of repeatability and reproducibility. This technique has already shown its potential on humans and animals through retrospective longitudinal studies and was published in many scientific journals (see references).
We therefore propose to make isotopic ratio measurements of copper (dCu) in serum or whole blood sample of your patients and deduce a risk level as to trigger or progression of a tumor pathology.
This technique is applicable to small domestic carnivores and is far better than TK1, Haptoglobine or C-reactive protein alone or mixed used as cancer biomarkers.
After a follow-up of two years on 77 dogs, we can say that our biomarker allows the diagnosis of > 80% of cancers (lymphoma) and this can go up to 99% if we add the measure of TK1. In addition, we were able to obtain more than 85% (copper alone) cancer recurrence detection over the two-years period of dog tracking. No other biomarker or biomarker combination achieves this level of performance.
Contact us for other species (including NAC). This type of analysis is also used for human tracking (links to references) contact us for details.
A paper is now online concerning our technology :
G. Chamel, A. T. Gourlan, P. Télouk, D. Sayag, V. Milliard, C. Loiseau, M. Simon, S. Buff and F. Ponce
Version of Record online: 6 OCT 2016 | DOI: 10.1111/vco.12273